Article
Attenuated vaccines can recombine to form virulent field viruses.
Science (New York, N.Y.) - 13 Jul 2012
Lee Sang-Won, Markham Philip F, Coppo Mauricio J C, Legione Alistair R, Markham John F, Noormohammadi Amir H, Browning Glenn F, Ficorilli Nino, Hartley Carol A, Devlin Joanne M
Abstract excerpt
Recombination between herpesviruses has been seen in vitro and in vivo under experimental conditions. This has raised safety concerns about using attenuated herpesvirus vaccines in human and veterinary medicine and adds to other known concerns associated with their use, including reversion to virulence and disease arising from recurrent reactivation of lifelong chronic infection. We used high-throughput...
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