Salicylic acid binds NPR3 and NPR4 to regulate NPR1-dependent defense responses.

doi:10.1038/cr.2012.100

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Article

Salicylic acid binds NPR3 and NPR4 to regulate NPR1-dependent defense responses.

Cell research - 1 Dec 2012

Moreau Magali, Tian Miaoying, Klessig Daniel F

Abstract excerpt

Salicylic acid (SA) is widely recognized as a key player in plant immunity. While several proteins have been previously identified as the direct targets of SA, SA-mediated plant defense signaling mechanisms remain unclear. The Nature paper from Xinnian Dong's group demonstrates that the NPR1 paralogues NPR3 and NPR4 directly bind SA, and this binding modulates their interaction with NPR1 and thereby degradation...

Topics

Arabidopsis
Arabidopsis Proteins
Mutation
Proteasome Endopeptidase Complex
Protein Binding
Salicylic Acid
Signal Transduction
Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 22785561
DOI: 10.1038/cr.2012.100
PMCID: PMC3515746

Genes

NPR1
NPR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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