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Article

A proposed consensus panel of organisms for determining evolutionary conservation of mt-tRNA point mutations.

Mitochondrion - 1 Sept 2012

Yarham John W, McFarland Robert, Taylor Robert W, Elson Joanna L

Abstract excerpt

Assigning pathogenicity to mt-tRNA variants requires multiple strands of evidence. Evolutionary conservation is often considered mandatory, but lack of a standard panel of organisms to assess conservation complicates comparison between reports and undermines the value of conservation-based evidence. We demonstrate that intra-species MTT sequence variation is sufficiently low for sequence data from a single...

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Share to Conserved Sequence
Share to Genes, Mitochondrial
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to RNA, Transfer

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Identifiers

PMID: 22781547
DOI: 10.1016/j.mito.2012.06.009
PMCID: PMC3510436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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