Article
Challenges and opportunities in genome-wide environmental interaction (GWEI) studies.
Human genetics - 1 Oct 2012
Aschard Hugues, Lutz Sharon, Maus Bärbel, Duell Eric J, Fingerlin Tasha E, Chatterjee Nilanjan, Kraft Peter, Van Steen Kristel
Abstract excerpt
The interest in performing gene-environment interaction studies has seen a significant increase with the increase of advanced molecular genetics techniques. Practically, it became possible to investigate the role of environmental factors in disease risk and hence to investigate their role as genetic effect modifiers. The understanding that genetics is important in the uptake and metabolism of toxic substances is...
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