Article
Extra copies of ALK gene locus is a recurrent genetic aberration and favorable prognostic factor in both ALK-positive and ALK-negative anaplastic large cell lymphomas.
Leukemia research - 1 Sept 2012
Yu Ran, Chen Gang, Zhou Chunju, Gao Zifen, Shi Yunfei, Shi Yan, Zhou Xiaoge, Xie Jianlan, Liu Hongxiang, Gong Liping
Abstract excerpt
Systemic anaplastic large cell lymphoma (ALCL) is subtyped into ALK-positive ALCL and ALK-negative ALCL based on the presence or absence of ALK protein expression. ALK-positive ALCL is characterized by t(2;5)(p23;q35)/NPM-ALK or variant ALK-involved translocations, while little is known about the genetic changes in ALK-negative ALCL. We investigated the structural and numerical aberrations of the ALK gene using...
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