Article
Use of next-generation sequencing and other whole-genome strategies to dissect neurological disease.
Nature reviews. Neuroscience - 20 Jun 2012
Bras Jose, Guerreiro Rita, Hardy John
Abstract excerpt
Over the past five years the field of neurogenetics has yielded a wealth of data that have facilitated a much greater understanding of the aetiology of many neurological diseases. Most of these advances are a result of improvements in technology that have allowed us to determine whole-genome structure and variation and to examine its impact on phenotype in an unprecedented manner. Genome-wide association studies...
Topics
- Animals
- Exome
- Genetic Linkage
- Genetic Predisposition to Disease
- Genetic Variation
- Genome-Wide Association Study
- Humans
- Nervous System Diseases
- Sequence Analysis, DNA