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Article

Comparative analysis of an expanded Clostridium difficile reference strain collection reveals genetic diversity and evolution through six lineages.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Oct 2012

Knetsch Cornelis W, Terveer Elisabeth M, Lauber Chris, Gorbalenya Alexander E, Harmanus Céline, Kuijper Ed J, Corver Jeroen, van Leeuwen Hans C

Abstract excerpt

Clostridium difficile is an anaerobic bacillus that resides in the gut and has rapidly emerged as a leading cause of antibiotic associated diarrheal disease in humans. The genetic basis of the pathogenicity of C. difficile remains poorly understood. In this study we aimed at characterizing the genetic diversity of C. difficile strains by three different methods (PCR ribotyping, multilocus sequence typing and...

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PMID: 22705462
DOI: 10.1016/j.meegid.2012.06.003

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