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Article

The pluripotency factor LIN28 in monkey and human testes: a marker for spermatogonial stem cells?

11 Jun 2012

Abstract excerpt

Mammalian spermatogenesis is maintained by spermatogonial stem cells (SSCs). However, since evidentiary assays and unequivocal markers are still missing in non-human primates (NHPs) and man, the identity of primate SSCs is unknown. In contrast, in mice, germ cell transplantation studies have functionally demonstrated the presence of SSCs. LIN28 is an RNA-binding pluripotent stem cell factor, which is also...

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PMID: 22689537
DOI: 10.1093/molehr/gas025

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