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Article

Linking disease symptoms and subtypes with personalized systems-based phenotypes: a proof of concept study.

Brain, behavior, and immunity - 1 Oct 2012

Aschbacher Kirstin, Adam Emma K, Crofford Leslie J, Kemeny Margaret E, Demitrack Mark A, Ben-Zvi Amos

Abstract excerpt

A dynamic systems model was used to generate parameters describing a phenotype of Hypothalamic-Pituitary-Adrenal (HPA) behavior in a sample of 36 patients with chronic fatigue syndrome (CFS) and/or fibromyalgia (FM) and 36 case-matched healthy controls. Altered neuroendocrine function, particularly in relation to somatic symptoms and poor sleep quality, may contribute to the pathophysiology of these disorders....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22687333
DOI: 10.1016/j.bbi.2012.06.002
PMCID: PMC3725324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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