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Article

Colonizing the world in spite of reduced MHC variation.

Journal of evolutionary biology - 1 Jul 2012

Gangoso L, Alcaide M, Grande J M, Muñoz J, Talbot S L, Sonsthagen S A, Sage G K, Figuerola J

Abstract excerpt

The major histocompatibility complex (MHC), which harbours the most polymorphic vertebrate genes, plays a critical role in the host-pathogen coevolutionary arms race. However, the extent to which MHC diversity determines disease susceptibility and long-term persistence of populations is currently under debate, as recent studies have demonstrated that low MHC variability does not necessarily hamper population...

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PMID: 22686489
DOI: 10.1111/j.1420-9101.2012.02529.x

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