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Article

KRAS mutation status and clinical outcome of preoperative chemoradiation with cetuximab in locally advanced rectal cancer: a pooled analysis of 2 phase II trials.

International journal of radiation oncology, biology, physics - 1 Jan 2013

Kim Sun Young, Shim Eun Kyung, Yeo Hyun Yang, Baek Ji Yeon, Hong Yong Sang, Kim Dae Yong, Kim Tae Won, Kim Jee Hyun, Im Seock-Ah, Jung Kyung Hae, Chang Hee Jin

Abstract excerpt

PURPOSE: Cetuximab-containing chemotherapy is known to be effective for KRAS wild-type metastatic colorectal cancer; however, it is not clear whether cetuximab-based preoperative chemoradiation confers an additional benefit compared with chemoradiation without cetuximab in patients with locally advanced rectal cancer. METHODS AND MATERIALS: We analyzed EGFR, KRAS, BRAF, and PIK3CA mutation status with direct...

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Topics

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Share to Capecitabine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22672749
DOI: 10.1016/j.ijrobp.2012.03.048

Genes

KRAS
EGFR
BRAF
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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