Article
H. pylori clinical isolates have diverse babAB genotype distributions over different topographic sites of stomach with correlation to clinical disease outcomes.
BMC microbiology - 30 May 2012
Sheu Shew-Meei, Sheu Bor-Shyang, Chiang Wen-Cheng, Kao Cheng-Yen, Wu Hsiu-Mei, Yang Hsiao-Bai, Wu Jiunn-Jong
Abstract excerpt
BACKGROUND: Intragenomic recombination between babA and babB mediates antigenic variations and may help H. pylori colonization. This study determined whether variable genotypes of babA and babB correlate to different clinical disease outcomes, and can distribute over the different gastric niches. RESULTS: This study enrolled 92 clinical strains (45 from peptic ulcer, 27 from gastritis, and 20 from gastric cancer)...
Topics
- Adhesins, Bacterial
- Amino Acid Substitution
- Bacterial Outer Membrane Proteins
- DNA, Bacterial
- Gastritis
- Genotype
- Helicobacter Infections
- Helicobacter pylori
- Humans
- Peptic Ulcer
- Sequence Analysis, DNA
- Stomach
- Stomach Neoplasms