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Article

IGF2/H19 hypomethylation in a patient with very low birthweight, preocious pubarche and insulin resistance.

BMC medical genetics - 30 May 2012

Murphy Rinki, Ibáñez Lourdes, Hattersley Andrew, Tost Jörg

Abstract excerpt

BACKGROUND: Insulin like growth factor 2 (IGF2) is an imprinted gene, which has an important role in fetal growth as established in mice models. IGF2 is downregulated through hypomethylation of a differentially methylated region (DMR) in Silver Russell syndrome (SRS), characterised by growth restriction. We have previously reported that severe pre- and post-natal growth restriction associated with insulin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22646060
DOI: 10.1186/1471-2350-13-42
PMCID: PMC3459807

Genes

IGF2
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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IGF2/H19 hypomethylation in a patient with very low birthweight, preocious pubarche and insulin resistance.PMID 22646060Read ↗

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