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[Evaluation of penicillin-binding protein genotypes in penicillin susceptible and resistant Streptococcus pneumoniae isolates].

Mikrobiyoloji bulteni - 1 Apr 2012

Aslan Gönül, Tezcan Seda, Delialioğlu Nuran, Aydın Fatma Esin, Kuyucu Necdet, Emekdaş Gürol

Abstract excerpt

Penicillin-binding proteins (PBPs) are the natural targets of beta-lactam antibiotics and mutations in pbp1a, pbp2b, and pbp2x genes, which encode PBPs, are responsible for resistance to beta-lactams in Streptococcus pneumoniae. In the present study, we intended to determine how often the common mutation patterns occurred within the pbp1a, pbp2b, and pbp2x PBP gene regions and evaluate the PBP genotype mutations...

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PMID: 22639308

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