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Article

Epigenetic inactivation of DNA repair in breast cancer.

Cancer letters - 28 Jan 2014

Nowsheen Somaira, Aziz Khaled, Tran Phuoc T, Gorgoulis Vassilis G, Yang Eddy S, Georgakilas Alexandros G

Abstract excerpt

The study of epigenetic mechanisms in cancer, such as DNA methylation and histone modifications, has revealed a plethora of events that contribute to cancer through stable changes in the expression of genes critical to transformation pathways. In this mini review we look at the different epigenetic modifications prevalent in this neoplastic phenotype, focusing on breast cancer. Most encouragingly, research in...

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Identifiers

PMID: 22634493
DOI: 10.1016/j.canlet.2012.05.015

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