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Self-renewal and multipotency coexist in a long-term cultured adult rat dental pulp stem cell line: an exception to the rule?

Stem cells and development - 10 Dec 2012

Sprio Andrea E, Di Scipio Federica, Raimondo Stefania, Salamone Paolina, Pagliari Francesca, Pagliari Stefania, Folino Anna, Forte Giancarlo, Geuna Stefano, Di Nardo Paolo, Berta Giovanni N

Abstract excerpt

The stemness state is characterized by self-renewal and differentiation properties. However, stem cells are not able to preserve these characteristics in long-term culture because of the intrinsic fragility of their phenotype easily undergoing senescence or neoplastic transformation. Furthermore, although isolated from the same original tissue using similar protocols, adult stem cells can display dissimilar...

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PMID: 22582744
DOI: 10.1089/scd.2012.0141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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