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Article

Laforin is required for the functional activation of malin in endoplasmic reticulum stress resistance in neuronal cells.

The FEBS journal - 1 Jul 2012

Zeng Li, Wang Yin, Baba Otto, Zheng Pan, Liu Yang, Liu Yan

Abstract excerpt

Mutations in either EPM2A, the gene encoding a dual-specificity phosphatase named laforin, or NHLRC1, the gene encoding an E3 ubiquitin ligase named malin, cause Lafora disease in humans. Lafora disease is a fatal neurological disorder characterized by progressive myoclonus epilepsy, severe neurological deterioration and accumulation of poorly branched glycogen inclusions, called Lafora bodies or polyglucosan...

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Identifiers

PMID: 22578008
DOI: 10.1111/j.1742-4658.2012.08627.x
PMCID: PMC3407668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Laforin is required for the functional activation of malin in endoplasmic reticulum stress resistance in neuronal cells.PMID 22578008Read ↗

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