Article
Enhanced identification of familial hypercholesterolemia using central laboratory algorithms.
Atherosclerosis - 1 Jun 2024
Ibrahim Shirin, Nurmohamed Nick S, Nierman Melchior C, de Goeij Jim N, Zuurbier Linda, van Rooij Jeroen, Schonck Willemijn A M, de Vries Jard, Hovingh G Kees, Reeskamp Laurens F, Stroes Erik S G
Abstract excerpt
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a highly prevalent genetic disorder resulting in markedly elevated LDL cholesterol levels and premature coronary artery disease. FH underdiagnosis and undertreatment require novel detection methods. This study evaluated the effectiveness of using an LDL cholesterol cut-off ≥99.5th percentile (sex- and age-adjusted) to identify clinical and genetic FH, and...
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