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Article

<i>Notch, Wnt,</i>and<i>Hedgehog</i>Pathways in Rhabdomyosarcoma: From Single Pathways to an Integrated Network

1 Jan 2012

Abstract excerpt

Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children. Regarding histopathological criteria, RMS can be divided into 2 main subtypes: embryonal and alveolar. These subtypes differ considerably in their clinical phenotype and molecular features. Abnormal regulation or mutation of signalling pathways that regulate normal embryonic development such as Notch, Hedgehog, and Wnt is a...

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PMID: 22550422
DOI: 10.1155/2012/695603

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