Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ribonucleotide Reductase Large Subunit ( RRM1 ) Gene Expression May Predict Efficacy of Adjuvant Mitotane in Adrenocortical Cancer

1 May 2012

Abstract excerpt

PURPOSE: Mitotane is the most broadly used systemic therapy for adrenocortical carcinoma (ACC), but its mechanism of action and possible predictors of treatment response are currently poorly defined. Our aim was to evaluate the gene expression of ribonucleotide reductase large subunit 1 (RRM1) and excision repair cross-complementation group 1 (ERCC1) in ACC as potential biomarkers for clinical outcome and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal and Paraganglionic Tumors
Share to Cancer, Hypoxia, and Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22547773
DOI: 10.1158/1078-0432.ccr-11-2692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ribonucleotide Reductase Large Subunit ( RRM1 ) Gene Expression May Predict Efficacy of Adjuvant Mitotane in Adrenocortical CancerPMID 22547773Read ↗

Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma TreatmentSemantic proximity Read ↗

Pathobiology and genetics of adrenocortical carcinomaSemantic proximity Read ↗

Molecular basis of adrenocortical carcinomas.Semantic proximity Read ↗

Diagnosis, treatment and outcome of adrenocortical cancer.Semantic proximity Read ↗

Adrenocortical carcinoma.Semantic proximity Read ↗

Long noncoding RNA profiles of adrenocortical cancer can be used to predict recurrence.Semantic proximity Read ↗

Genomic and Expression Profiling of Adrenocortical Carcinoma: Application to Diagnosis, Prognosis and TreatmentSemantic proximity Read ↗

Targeted Therapy for Adrenocortical Carcinoma: A Genomic-Based Search for Available and Emerging OptionsSemantic proximity Read ↗

Nutlin-3a as a novel anticancer agent for adrenocortical carcinoma with CTNNB1 mutation.Semantic proximity Read ↗

Rapid and Complete Remission of Metastatic Adrenocortical Carcinoma Persisting 10 Years After Treatment With Mitotane Monotherapy: Case Report and Review of the Literature.Semantic proximity Read ↗

Identifying New Potential Biomarkers in Adrenocortical Tumors Based on mRNA Expression Data Using Machine LearningSemantic proximity Read ↗

Targeted Gene Expression Profile Reveals CDK4 as Therapeutic Target for Selected Patients With Adrenocortical CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.