Article
Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III).
BMC medical genetics - 27 Apr 2012
Grimsby Jonna L, Porneala Bianca C, Vassy Jason L, Yang Quanhe, Florez José C, Dupuis Josée, Liu Tiebin, Yesupriya Ajay, Chang Man-Huei, Ned Renee M, Dowling Nicole F, Khoury Muin J, Meigs James B
Abstract excerpt
BACKGROUND: Hemoglobin A1c (HbA1c) levels diagnose diabetes, predict mortality and are associated with ten single nucleotide polymorphisms (SNPs) in white individuals. Genetic associations in other race groups are not known. We tested the hypotheses that there is race-ethnic variation in 1) HbA1c-associated risk allele frequencies (RAFs) for SNPs near SPTA1, HFE, ANK1, HK1, ATP11A, FN3K, TMPRSS6, G6PC2, GCK,...
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