Article
Exploring functionally related enzymes using radially distributed properties of active sites around the reacting points of bound ligands.
BMC structural biology - 26 Apr 2012
Ueno Keisuke, Mineta Katsuhiko, Ito Kimihito, Endo Toshinori
Abstract excerpt
BACKGROUND: Structural genomics approaches, particularly those solving the 3D structures of many proteins with unknown functions, have increased the desire for structure-based function predictions. However, prediction of enzyme function is difficult because one member of a superfamily may catalyze a different reaction than other members, whereas members of different superfamilies can catalyze the same reaction....
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