Article
Single-nucleotide polymorphisms and haplotypes of membrane type 1-matrix metalloproteinase in susceptibility and clinical significance of squamous cell neoplasia of uterine cervix in Taiwan women.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Sept 2012
Tee Yi-Torng, Liu Yu-Fan, Chang Jinghua Tsai, Yang Shun-Fa, Chen Shiuan-Chih, Han Chih-Ping, Wang Po-Hui, Liao Chiung-Ling
Abstract excerpt
Membrane type 1-matrix metalloproteinase (MT1-MMP) participates in the activity of MMP-2, which correlates with cancer of uterine cervix. Single-nucleotide polymorphisms (SNPs) in promoter and exon of MT1-MMP may influence their binding with transcription factors and gene transcription. To date, no study reports the association of the MT1-MMP polymorphisms with cervical neoplasia. Therefore, we investigated the...
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