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Cell surface associated glycohydrolases in normal and Gaucher disease fibroblasts

18 Apr 2012

Abstract excerpt

Gaucher disease (GD) is the most common lysosomal disorder and is caused by an inherited autosomal recessive deficiency in β-glucocerebrosidase. This enzyme, like other glycohydrolases involved in glycosphingolipid (GSL) metabolism, is present in both plasma membrane (PM) and intracellular fractions. We analyzed the activities of CBE-sensitive β-glucosidase (GBA1) and AMP-DNM-sensitive β-glucosidase (GBA2) in...

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PMID: 22526844
DOI: 10.1007/s10545-012-9478-x

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