Article
Case report of apoptosis in testis of four AZFc-deleted patients: increased DNA fragmentation during meiosis, but decreased apoptotic markers in post-meiotic germ cells.
Human reproduction (Oxford, England) - 1 Jul 2012
Streichemberger Eric, Perrin Jeanne, Saias-Magnan Jacqueline, Karsenty Gilles, Malzac Perrine, Grillo Jean-Marie, Mitchell Michael J, Metzler-Guillemain Catherine
Abstract excerpt
AZFc deletions of the Y chromosome are the major known genetic cause of spermatogenetic failure. Meiotic studies have shown a prevalence of synaptonemal complex fragmentation and an excess of early-stage sperm cells, suggesting that the maturation block could involve apoptosis. We present a prosp...
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