Article
Epstein-Barr virus protein EB2 stimulates cytoplasmic mRNA accumulation by counteracting the deleterious effects of SRp20 on viral mRNAs.
Nucleic acids research - 1 Aug 2012
Juillard Franceline, Bazot Quentin, Mure Fabrice, Tafforeau Lionel, Macri Christophe, Rabourdin-Combe Chantal, Lotteau Vincent, Manet Evelyne, Gruffat Henri
Abstract excerpt
The Epstein-Barr Virus (EBV) protein EB2 (also called Mta, SM and BMLF1), is an essential nuclear protein produced during the replicative cycle of EBV. EB2 is required for the efficient cytoplasmic accumulation of viral mRNAs derived from intronless genes. EB2 is an RNA-binding protein whose expression has been shown to influence RNA stability, splicing, nuclear export and translation. Using a yeast two-hybrid...
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