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A rat model of Staphylococcus aureus chronic osteomyelitis that provides a suitable system for studying the human infection

1 Nov 1990

Abstract excerpt

Chronic osteomyelitis was produced by inoculating Staphylococcus aureus into rat tibia. The infection was characterised grossly by bone deformation and histopathologically by inflammation and the presence of coccal organisms sequestered within the bone tissue. Further observations by scanning electronmicroscopy demonstrated bacteria in microcolonies surrounded by dehydrated amorphous material that was considered...

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PMID: 2250289
DOI: 10.1099/00222615-33-3-189

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