Article
Quantifying the natural history of biofilm formation in vivo during the establishment of chronic implant-associated Staphylococcus aureus osteomyelitis in mice to identify critical pathogen and host factors.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Sept 2015
Nishitani Kohei, Sutipornpalangkul Werasak, de Mesy Bentley Karen L, Varrone John J, Bello-Irizarry Sheila N, Ito Hiromu, Matsuda Shuichi, Kates Stephen L, Daiss John L, Schwarz Edward M
Abstract excerpt
While it is well known that Staphylococcus aureus establishes chronic implant-associated osteomyelitis by generating and persisting in biofilm, research to elucidate pathogen, and host specific factors controlling this process has been limited due to the absence of a quantitative in vivo model. To address this, we developed a murine tibia implant model with ex vivo region of interest (ROI) imaging analysis by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.