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Article

Genetic and environmental influences of white and gray matter signal contrast: a new phenotype for imaging genetics?

NeuroImage - 15 Apr 2012

Panizzon Matthew S, Fennema-Notestine Christine, Kubarych Thomas S, Chen Chi-Hua, Eyler Lisa T, Fischl Bruce, Franz Carol E, Grant Michael D, Hamza Samar, Jak Amy, Jernigan Terry L, Lyons Michael J, Neale Michael C, Prom-Wormley Elizabeth C, Seidman Larry, Tsuang Ming T, Wu Hao, Xian Hong, Dale Anders M, Kremen William S

Abstract excerpt

The estimation of cortical thickness is in part dependent on the degree of contrast in T1 signal intensity between white matter and gray matter along the cortical mantle. The ratio of white matter to gray matter signal (WM/GM contrast) has been found to vary as a function of age and Alzheimer's disease status, suggesting a biological component to what might otherwise be labeled as a nuisance variable. The aim of...

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Identifiers

PMID: 22500923
DOI: 10.1016/j.neuroimage.2012.01.122
PMCID: PMC3328105

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