Article
Analysis of mutations in the BCR-ABL1 kinase domain, using direct sequencing: detection of the T315I mutation in bone marrow CD34+ cells of a patient with chronic myelogenous leukemia 6 months prior to its emergence in peripheral blood.
Molecular diagnosis & therapy - 1 Jun 2012
Razga Filip, Jurcek Tomas, Jeziskova Ivana, Zackova Daniela, Dvorakova Dana, Borsky Marek, Mayer Jiri, Racil Zdenek
Abstract excerpt
BACKGROUND AND OBJECTIVE: It has been shown that the occurrence of the BCR-ABL1 T315I mutation leads to a very poor therapeutic outcome in chronic myelogenous leukemia (CML) patients treated with tyrosine kinase inhibitors. Therefore, early detection of this mutation could potentially lead to early therapeutic intervention and a better prognosis with the ongoing treatment regimen. METHODS: The detection of...
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