Article
Cancer and longevity--is there a trade-off? A study of cooccurrence in Danish twin pairs born 1900-1918.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 May 2012
Christensen Kaare, Pedersen Jacob K, Hjelmborg Jacob V B, Vaupel James W, Stevnsner Tinna, Holm Niels V, Skytthe Axel
Abstract excerpt
BACKGROUND: Animal models and a few human studies have suggested a complex interaction between cancer risk and longevity indicating a trade-off where low cancer risk is associated with accelerating aging phenotypes and, vice versa, that longevity potential comes with the cost of increased cancer risk. This hypothesis predicts that longevity in one twin is associated with increased cancer risk in the cotwin....
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