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Article

Overcoming castration resistance in prostate cancer.

Current opinion in urology - 1 May 2012

Tsao Che-Kai, Small Alexander C, Galsky Matthew D, Oh William K

Abstract excerpt

PURPOSE OF REVIEW: Recent advances in our understanding of the androgen axis signaling pathway have led to the development of therapeutic strategies to overcome the state of 'castration resistance' in prostate cancer. In this review, we examine the mechanisms of castration resistance, as well as recently reported and ongoing clinical studies, which will further identify therapeutic opportunities for novel...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22472508
DOI: 10.1097/MOU.0b013e3283523b8b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Overcoming castration resistance in prostate cancer.PMID 22472508Read ↗

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Targeting extra-gonadal androgens in castration-resistant prostate cancer.Semantic proximity Read ↗

Beyond simple castration: targeting the molecular basis of treatment resistance in advanced prostate cancerSemantic proximity Read ↗

Targeting the androgen receptor pathway in castration-resistant prostate cancer: progresses and prospectsSemantic proximity Read ↗

Overcoming drug resistance in castrate-resistant prostate cancer: current mechanisms and emerging therapeutic approachesSemantic proximity Read ↗

Targeting the androgen receptor and overcoming resistance in prostate cancerSemantic proximity Read ↗

[Molecular biology of castration-resistant prostate cancer].Semantic proximity Read ↗

Novel hormone therapies for advanced prostate cancer: Understanding and countering drug resistanceSemantic proximity Read ↗

Androgen Receptor Signaling Pathway in Prostate Cancer: From Genetics to Clinical ApplicationsSemantic proximity Read ↗

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