Article
Morphologic and immunohistochemical characterization of granulomas in the nucleotide oligomerization domain 2-related disorders Blau syndrome and Crohn disease.
The Journal of allergy and clinical immunology - 1 Apr 2012
Janssen Carl E I, Rose Carlos D, De Hertogh Gert, Martin Tammy M, Bader Meunier Brigitte, Cimaz Rolando, Harjacek Miroslav, Quartier Pierre, Ten Cate Rebecca, Thomee Caroline, Desmet Valeer J, Fischer Alain, Roskams Tania, Wouters Carine H
Abstract excerpt
BACKGROUND: Blau syndrome (BS) and Crohn disease (CD) are both characterized by granulomatous inflammation and related to nucleotide oligomerization domain 2 (NOD2) mutations. OBJECTIVE: This study aimed to define the morphologic and immunohistochemical characteristics of granulomas in patients with NOD2-related BS and CD. METHODS: Granuloma-containing biopsy specimens from 6 patients with BS and 7 pediatric...
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