Article
Non tumoral hyperserotoninaemia responsive to octreotide due to dual polymorphism in UGT1A1 and UGT1A6.
Hormones (Athens, Greece) - 1 Jan 2000
Maladaki Anna, Yavropoulou Maria P, Kotsa Kalliopi, Tranga Theoni, Ventis Stelios, Yovos John G
Abstract excerpt
Gilbert's syndrome is a common inherited metabolic disorder, caused by genetic aberration in the enzyme UDP-glucuronosyl-transferase 1A1 that leads to reduced glucuronidation of bilirubin. Recent advances in molecular genetics have frequently reported the concurrence of dual genetic polymorphisms in UDP glucuronosyl-transferases 1A6 and 1A1 in patients with Gilbert's syndrome, leading to defective glucuronidation...
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