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Article

Developmental genetics of secretory vesicle acidification during Caenorhabditis elegans spermatogenesis.

Genetics - 1 Jun 2012

Gleason Elizabeth J, Hartley Paul D, Henderson Melissa, Hill-Harfe Katherine L, Price Paul W, Weimer Robby M, Kroft Tim L, Zhu Guang-Dan, Cordovado Suzanne, L'Hernault Steven W

Abstract excerpt

Secretory vesicles are used during spermatogenesis to deliver proteins to the cell surface. In Caenorhabditis elegans, secretory membranous organelles (MO) fuse with the plasma membrane to transform spermatids into fertilization-competent spermatozoa. We show that, like the acrosomal vesicle of mammalian sperm, MOs undergo acidification during development. Treatment of spermatids with the V-ATPase inhibitor...

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Identifiers

PMID: 22446317
DOI: 10.1534/genetics.112.139618
PMCID: PMC3374312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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