Article
Developmental genetics of secretory vesicle acidification during Caenorhabditis elegans spermatogenesis.
Genetics - 1 Jun 2012
Gleason Elizabeth J, Hartley Paul D, Henderson Melissa, Hill-Harfe Katherine L, Price Paul W, Weimer Robby M, Kroft Tim L, Zhu Guang-Dan, Cordovado Suzanne, L'Hernault Steven W
Abstract excerpt
Secretory vesicles are used during spermatogenesis to deliver proteins to the cell surface. In Caenorhabditis elegans, secretory membranous organelles (MO) fuse with the plasma membrane to transform spermatids into fertilization-competent spermatozoa. We show that, like the acrosomal vesicle of mammalian sperm, MOs undergo acidification during development. Treatment of spermatids with the V-ATPase inhibitor...
Topics
- Amino Acid Sequence
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Gene Expression
- Male
- Molecular Sequence Data
- Mutation
- Protein Transport
- Secretory Vesicles