Article
Total activity of glutathione-S-transferase (GST) and polymorphisms of GSTM1 and GSTT1 genes conferring risk for the development of age related cataracts.
Experimental eye research - 1 May 2012
Sireesha R, Laxmi S G Bhagya, Mamata M, Reddy P Yadagiri, Goud P Upender, Rao P Venkateshwar, Reddy G Bhanuprakash, Vishnupriya S, Padma T
Abstract excerpt
The pathogenesis of cataract is influenced by a number of factors including oxidative stress. Glutathione-S-transferase (GST) catalyses the nucleophilic addition of the thiol of GSH to electrophilic acceptors. It is important for detoxification of xenobiotics in order to protect tissues from oxidative damage. In humans, GSTT1 and GSTM1 deletion genotypes are associated with a variety of pathological conditions...
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