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Article

Proof of concept of microbiome-metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at-risk infants.

PloS one - 1 Jan 2012

Sellitto Maria, Bai Guoyun, Serena Gloria, Fricke W Florian, Sturgeon Craig, Gajer Pawel, White James R, Koenig Sara S K, Sakamoto Joyce, Boothe Dustin, Gicquelais Rachel, Kryszak Deborah, Puppa Elaine, Catassi Carlo, Ravel Jacques, Fasano Alessio

Abstract excerpt

Celiac disease (CD) is a unique autoimmune disorder in which the genetic factors (DQ2/DQ8) and the environmental trigger (gluten) are known and necessary but not sufficient for its development. Other environmental components contributing to CD are poorly understood. Studies suggest that aspects of gluten intake might influence the risk of CD occurrence and timing of its onset, i.e., the amount and quality of...

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Identifiers

PMID: 22432018
DOI: 10.1371/journal.pone.0033387
PMCID: PMC3303818

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