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Article

From GHRH to IGF-1 and downstream: clinical phenotypes and biological mechanisms.

Pediatric endocrinology reviews : PER - 1 Sept 2011

Pfäffle Roland, Kies Wieland, Klammt Jürgen

Abstract excerpt

Genetic defects have been observed at almost all levels of the GHRH-IGF-1 axis. The first observations of GH-1 gene deletions date some 30 years ago. Whereas mutations in the GH-1 and GHRHR genes account for the majority of mutations detectable in patients with Isolated Growth Hormone Deficiency (IGHD) resulting in postnatal growth failure, the overall detection of genetic defects in these patients remains low...

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Source

Identifiers

PMID: 22423511

Genes

GHRH
GHRHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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