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Role of porcine reproductive and respiratory syndrome virus nucleocapsid protein in induction of interleukin-10 and regulatory T-lymphocytes (Treg)

15 Mar 2012

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV) infection induces interleukin (IL)-10 production and increased numbers of PRRSV-specific regulatory T-lymphocytes in infected pigs. In the present study, the roles of the nucleocapsid (N) protein in induction of IL-10 and CD4(+)CD25(+)Foxp3(+) lymphocytes (T(reg)) were investigated. Transfection of porcine monocyte-derived dendritic cells (MoDCs) and...

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PMID: 22422061
DOI: 10.1099/vir.0.040287-0

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