Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring concordance and discordance for return of incidental findings from clinical sequencing.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Apr 2012

Green Robert C, Berg Jonathan S, Berry Gerard T, Biesecker Leslie G, Dimmock David P, Evans James P, Grody Wayne W, Hegde Madhuri R, Kalia Sarah, Korf Bruce R, Krantz Ian, McGuire Amy L, Miller David T, Murray Michael F, Nussbaum Robert L, Plon Sharon E, Rehm Heidi L, Jacob Howard J

Abstract excerpt

PURPOSE: The aim of this study was to explore specific conditions and types of genetic variants that specialists in genetics recommend should be returned as incidental findings in clinical sequencing. METHODS: Sixteen specialists in clinical genetics and/or molecular medicine selected variants in 99 common conditions to return to the ordering physician if discovered incidentally through whole-genome sequencing....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetics, Medical

Share to Genome, Human

Share to Incidental Findings

Share to Mutation

Share to Sequence Analysis, DNA

Share to Truth Disclosure

Source

Open in PubMed Open full text

Identifiers

PMID: 22422049
DOI: 10.1038/gim.2012.21
PMCID: PMC3763716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring concordance and discordance for return of incidental findings from clinical sequencing.PMID 22422049Read ↗

Recommendations for returning genomic incidental findings? We need to talk!Semantic proximity Read ↗

Processes and preliminary outputs for identification of actionable genes as incidental findings in genomic sequence data in the Clinical Sequencing Exploratory Research Consortium.Semantic proximity Read ↗

Frequency and management of medically actionable incidental findings from genome and exome sequencing data: a systematic review.Semantic proximity Read ↗

Incidental Findings from Clinical Genome‐Wide Sequencing: A ReviewSemantic proximity Read ↗

Patient decisions for disclosure of secondary findings among the first 200 individuals undergoing clinical diagnostic exome sequencingSemantic proximity Read ↗

Patients' views on incidental findings from clinical exome sequencingSemantic proximity Read ↗

Opportunistic screening for broad range of medically relevant secondary findings: Laboratory benefits and burdens.Semantic proximity Read ↗

Incidental medical information in whole-exome sequencing.Semantic proximity Read ↗

Perspectives of clinical genetics professionals toward genome sequencing and incidental findings: a survey studySemantic proximity Read ↗

Genetics specialists’ perspectives on disclosure of genomic incidental findings in the clinical settingSemantic proximity Read ↗

Genome sequencing and carrier testing: decisions on categorization and whether to disclose results of carrier testingSemantic proximity Read ↗

Assessment of incidental findings in 232 whole-exome sequences from the Baylor-Hopkins Center for Mendelian Genomics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.