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Profiles in Leukemia

14 Mar 2012

Abstract excerpt

For years, scientists have postulated the evolution of a cancer as a series of acquired mutations and epigenetic alterations that accumulate in a progressive way, beginning with a single transformed cell. Within this process, subclones of cells develop that acquire new properties, giving cells advantages, such as the ability to resist chemotherapy or to metastasize. With the publication of two articles in this...

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PMID: 22417205
DOI: 10.1056/nejme1200409

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