Article
[SNP-specific mismatched PCR for embryonic DNA detection using blood from pregnant mothers].
Rinsho byori. The Japanese journal of clinical pathology - 1 Jan 2012
Kobayashi Miwa, Matsuda Kazuyuki, Terasawa Fumiko, Okumura Nobuo, Honda Takayuki, Yoshikawa Fumihiko, Netsu Yahiro
Abstract excerpt
BACKGROUND: Although prenatal diagnoses are performed using amniotic fluid cells, chorionic villus, or cord blood, these methods are hazardous for pregnant woman and the fetus. To determine a procedure for safe prenatal diagnosis, we have developed a sensitive method to analyze SNPs and we evaluated the possibility to detect fetal DNA in the maternal blood. METHODS: GeneScan analysis was performed by using...
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