Article
Prevalence of Huntington's disease gene CAG repeat alleles in sporadic amyotrophic lateral sclerosis patients.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases - 1 May 2012
Ramos Eliana Marisa, Keagle Pamela, Gillis Tammy, Lowe Patrick, Mysore Jayalakshmi S, Leclerc Ashley Lyn, Ratti Antonia, Ticozzi Nicola, Gellera Cinzia, Gusella James F, Silani Vincenzo, Alonso Isabel, Brown Robert H, MacDonald Marcy E, Landers John E
Abstract excerpt
A higher prevalence of intermediate ataxin-2 CAG repeats in amyotrophic lateral sclerosis (ALS) patients has raised the possibility that CAG expansions in other polyglutamine disease genes could contribute to ALS neurodegeneration. We sought to determine whether expansions of the CAG repeat of the HTT gene that causes Huntington's disease, are associated with ALS. We compared the HTT CAG repeat length on a total...
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