Molecular analysis of the heterogeneity among the P-family of alpha-1-antitrypsin alleles.

doi:10.1164/ajrccm/142.5.1185

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Article

Molecular analysis of the heterogeneity among the P-family of alpha-1-antitrypsin alleles.

The American review of respiratory disease - 1 Nov 1990

Holmes M D, Brantly M L, Crystal R G

Abstract excerpt

The rare P-family of alpha 1-antitrypsin (alpha 1AT) variants is defined by the position of migration of the alpha 1AT protein on isoelectric focusing of serum (IEF) between the common M and S variants. To begin to examine the molecular heterogeneity among the P-type alleles, two unrelated subjects and their families identified by IEF to be carrying a P allele were analyzed. The first, Plowell, is a deficiency...

Topics

Aged
Alleles
Base Sequence
Female
Gene Amplification
Genotype
Heterozygote
Humans
Isoelectric Focusing
Male
Middle Aged
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Pedigree

Phenotype

Protein Biosynthesis

alpha 1-Antitrypsin

alpha 1-Antitrypsin Deficiency

Source

Open in PubMed

Identifiers

PMID: 2240842
DOI: 10.1164/ajrccm/142.5.1185

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2240842-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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