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Article

The possible underlying pathophysiological mechanisms for development of multiple sclerosis in familial Mediterranean fever.

Medical hypotheses - 1 Jun 2012

Alpayci Mahmut, Bozan Nazim, Erdem Seyfettin, Gunes Muslum, Erden Metin

Abstract excerpt

Patients with familial Mediterranean fever (FMF) have a susceptibility to the development of multiple sclerosis (MS). Here, we will propose the possible underlying pathophysiological mechanisms of this predisposition. Inflammation, disruption of blood-brain barrier (BBB), mitochondrial energy deficit, demyelination, and axonal damage, which play an important role in the pathogenesis of MS, may occur during the...

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Source

Identifiers

PMID: 22406096
DOI: 10.1016/j.mehy.2012.02.017

Genes

MEFV

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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