Article
[Familial Mediterranean fever].
La Revue de medecine interne - 1 Apr 2018
Georgin-Lavialle S, Hentgen V, Stankovic Stojanovic K, Bachmeyer C, Rodrigues F, Savey L, Abbara S, Conan P-L, Fraisse T, Delplanque M, Rouet A, Sbeih N, Koné-Paut I, Grateau G
Abstract excerpt
Familial Mediterranean Fever (FMF) is the most frequent monogenic auto-inflammatory disease. FMF is an autosomal recessive disease, which affects populations from Mediterranean origin and is associated with MEFV gene mutations encoding for the protein pyrin. Pyrin activation enhances the secretion of interleukin 1 by myelo-monocytic cells. Main features of the disease are acute attacks of serositis mainly located...
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