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Article

The Brugada syndrome mutation A39V does not affect surface expression of neuronal rat Cav1.2 channels.

Molecular brain - 2 Mar 2012

Simms Brett A, Zamponi Gerald W

Abstract excerpt

BACKGROUND: A loss of function of the L-type calcium channel, Cav1.2, results in a cardiac specific disease known as Brugada syndrome. Although many Brugada syndrome channelopathies reduce channel function, one point mutation in the N-terminus of Cav1.2 (A39V) has been shown to elicit disease a phenotype because of a loss of surface trafficking of the channel. This lack of cell membrane expression could not be...

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Identifiers

PMID: 22385640
DOI: 10.1186/1756-6606-5-9
PMCID: PMC3307476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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