Article
Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death.
Circulation - 30 Jan 2007
Antzelevitch Charles, Pollevick Guido D, Cordeiro Jonathan M, Casis Oscar, Sanguinetti Michael C, Aizawa Yoshiyasu, Guerchicoff Alejandra, Pfeiffer Ryan, Oliva Antonio, Wollnik Bernd, Gelber Philip, Bonaros Elias P, Burashnikov Elena, Wu Yuesheng, Sargent John D, Schickel Stefan, Oberheiden Ralf, Bhatia Atul, Hsu Li-Fern, Haïssaguerre Michel, Schimpf Rainer, Borggrefe Martin, Wolpert Christian
Abstract excerpt
BACKGROUND: Cardiac ion channelopathies are responsible for an ever-increasing number and diversity of familial cardiac arrhythmia syndromes. We describe a new clinical entity that consists of an ST-segment elevation in the right precordial ECG leads, a shorter-than-normal QT interval, and a hist...
Topics
- Adult
- Animals
- CHO Cells
- Calcium Channels
- Calcium Channels, L-Type
- Cricetinae
- Cricetulus
- Death, Sudden, Cardiac
- Electrocardiography