Article
A high variability of mixed infections and recent recombinations of hepatitis B virus in Laos.
PloS one - 1 Jan 2012
Andernach Iris E, Jutavijittum Prapan, Samountry Bounthome, Yousukh Amnat, Thammavong Te, Hübschen Judith M, Muller Claude P
Abstract excerpt
In Lao PDR, where more than 8% of the population are chronic carriers of HBsAg, multiple genotypes and subgenotypes co-circulate and are prone to generate recombinant viruses. Phylogenetic analyses of multiple clones per donor revealed mixed infections of subgenotypes B1, B2, B4, C1, C5, I1 and I2 in almost 6% of HBsAg positive rejected blood donors. Recombination analyses and distance calculations furthermore...
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