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Article

Immunoregulatory gene polymorphisms in Japanese women with preterm births and periodontitis.

Journal of reproductive immunology - 1 Mar 2012

Sugita Noriko, Kobayashi Tetsuo, Kikuchi Akira, Shimada Yasuko, Hirano Emi, Sasahara Jun, Tanaka Kenichi, Yoshie Hiromasa

Abstract excerpt

Many studies have reported an association between periodontal disease and preterm birth, although this remains controversial. Cytokines and antibodies produced to give resistance to infection can enter the bloodstream and cause preterm labor. We analyzed maternal genetic polymorphisms in various immunoregulatory genes that could affect both preterm birth and periodontitis. A total of 1099 women referred to the...

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PMID: 22382006
DOI: 10.1016/j.jri.2012.01.005

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